Acetic Anhydride → HCID 58413014, compound

HRID 240639Notes

Reaction equation

Cl.[F:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]2[C:11]3[C:18]([CH3:19])=[C:17]([C:20]([NH2:22])=[O:21])[S:16][C:12]=3[N:13]=[CH:14][N:15]=2)=[C:5]([O:23][C@@H:24]2[CH2:28][CH2:27][NH:26][CH2:25]2)[CH:4]=1.[C:29](OC(=O)C)(=[O:31])[CH3:30]>>[C:29]([N:26]1[CH2:27][CH2:28][C@@H:24]([O:23][C:5]2[CH:4]=[C:3]([F:2])[CH:8]=[CH:7][C:6]=2[NH:9][C:10]2[C:11]3[C:18]([CH3:19])=[C:17]([C:20]([NH2:22])=[O:21])[S:16][C:12]=3[N:13]=[CH:14][N:15]=2)[CH2:25]1)(=[O:31])[CH3:30]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 67394928HCID 67394928, compound

Product 1

HCID 58413014HCID 58413014, compound

Procedure

Prepared analogously to example 99.4 from 4-[4-fluoro-2-((R)-pyrrolidin-3-yloxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid amide hydrochloride and acetic anhydride.

Sources & evidence

ORD record: ord-477223d26fe44c1290013d21e85a67bc
Source dataset: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08648068B2

Reaction notes

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