p-Toluenesulfonic acid → HCID 58413084, compound

Participants

Reaction Conditions

Reaction Steps

4-Chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester (100 mg) and (R)-4-fluoro-2-(tetrahydrofuran-3-yloxy)aniline (Intermediate VI) (81 mg) was dissolved in Dioxan (2 ml) and p-Toluenesulfonic acid (15 mg) was added. The reaction heated at 110° C. under microwave radiation. The resultant precipitate was filtered and dissolved in dichloromethane/Methanol. The solution was dried and concentrated to give the desired product.

Provenance & Evidence