3-(Trifluoromethyl)phenol → HCID 23687391, compound

HRID 2406416Notes

Reaction equation

HRID 2406416 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[C:5]([OH:9])[CH:6]=[CH:7][CH:8]=1.CC(C)([O-])C.[K+:17]>>[F:1][C:2]([F:10])([F:11])[C:3]1[CH:4]=[C:5]([CH:6]=[CH:7][CH:8]=1)[O-:9].[K+:17]

Participants

3

Reactant 2

HCID 73763-(Trifluoromethyl)phenolHCID 23665647Potassium tert-butoxide

Product 1

HCID 23687391HCID 23687391, compound

Procedure

A mixture of 1.94 g (12 mmol) of 3-(trifluoromethyl)phenol and 1.344 g (12 mmol) of potassium t-butoxide was stirred under argon for 30 min. A solution was resulted, and the by-product, t-butanol, was removed under vacuum and heat to give a white solid.

Workup

  1. customA solution was resulted
  2. customthe by-product, t-butanol, was removed under vacuum
  3. temperatureheat
  4. customto give a white solid

Sources & evidence

ORD record
ord-434a4fbc335b4229864a4305064545c1
Source dataset
uspto-grants-2014_08
Patent number
US08809368B2

Reaction notes

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