HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonamide → HCID 58413203, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonamide | HCID 72879 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 58413081 | HCID 58413081 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Potassium bisulfate | HCID 516920 | — |
| Product | HCID 58413203 | HCID 58413203 | — |
Reaction Steps
4-{4-Fluoro-2-[(R)-(tetrahydro-furan-3-yl)oxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (150 mg), 4-dimethylaminopyridine (61 mg) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (96 mg) was dissolved in dichloromethane. To this mixture methanesulfonamide (48 mg) was added and the reaction was stirred overnight. The reaction mixture was diluted with KHSO4 The organic layer was separated, dried and concentrated. The residue was purified by silica chromatography (Dichloromethane/MeOH/NH3 10:1:0,1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08648068B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-b04cadab3227433f8a203c8f88c59811 |
| Source note | uspto-grants-2014_02 |