Methyl 4-chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate → HCID 58413080, compound

HRID 240646Notes

Reaction equation

HRID 240646 reaction equation
[CH3:1][O:2][C:3]([C:5]1[S:14][C:8]2[N:9]=[CH:10][N:11]=[C:12](Cl)[C:7]=2[C:6]=1[CH3:15])=[O:4].[NH2:16][C:17]1[CH:37]=[CH:36][C:35]([F:38])=[CH:34][C:18]=1[O:19][C@@H:20]1[CH2:24][N:23]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[C@H:22]([CH2:32][OH:33])[CH2:21]1>>[CH3:1][O:2][C:3]([C:5]1[S:14][C:8]2[N:9]=[CH:10][N:11]=[C:12]([NH:16][C:17]3[CH:37]=[CH:36][C:35]([F:38])=[CH:34][C:18]=3[O:19][C@H:20]3[CH2:21][C@@H:22]([CH2:32][OH:33])[N:23]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:24]3)[C:7]=2[C:6]=1[CH3:15])=[O:4]

Participants

3

Reactant 2

HCID 2759834Methyl 4-chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylateHCID 58413055HCID 58413055, compound

Product 1

HCID 58413080HCID 58413080, compound

Procedure

Prepared analogously to example 1.1 from 4-chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester and (2S,4S)-tert-butyl 4-(2-amino-5-fluorophenoxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate.

Sources & evidence

ORD record
ord-c45191f9705d41399317e8346cb2307b
Source dataset
uspto-grants-2014_02
Patent number
US08648068B2

Reaction notes

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