Methanesulfonyl chloride → HCID 58413193, compound

HRID 240649Notes

Reaction equation

Cl.[C:2]([C:5]1[S:32][C:8]2[N:9]=[CH:10][N:11]=[C:12]([NH:13][C:14]3[CH:30]=[CH:29][C:28]([F:31])=[CH:27][C:15]=3[O:16][C@@H:17]3[CH2:21][NH:20][C@H:19]([CH2:22][O:23][C:24](=[O:26])[CH3:25])[CH2:18]3)[C:7]=2[C:6]=1[CH3:33])(=[O:4])[NH2:3].[CH3:34][S:35](Cl)(=[O:37])=[O:36]>>[C:2]([C:5]1[S:32][C:8]2[N:9]=[CH:10][N:11]=[C:12]([NH:13][C:14]3[CH:30]=[CH:29][C:28]([F:31])=[CH:27][C:15]=3[O:16][C@@H:17]3[CH2:21][N:20]([S:35]([CH3:34])(=[O:37])=[O:36])[C@H:19]([CH2:22][O:23][C:24](=[O:26])[CH3:25])[CH2:18]3)[C:7]=2[C:6]=1[CH3:33])(=[O:4])[NH2:3]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride2×

HCID 67395638HCID 67395638, compound

Product 1

HCID 58413193HCID 58413193, compound

Procedure

Prepared analogously to example 10.2 from acetic acid (2S,4S)-4-[2-(6-carbamoyl-5-methyl-thieno[2,3-d]pyrimidin-4-ylamino)-5-fluoro-phenoxy]-pyrrolidin-2-ylmethyl ester hydrochloride and methanesulfonyl chloride. Methansulfonyl chloride was added at 0° C.

Sources & evidence

ORD record: ord-896923ba33dd4114a69f63708a1fe982
Source dataset: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08648068B2

Reaction notes

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