Trifluoroacetic acid → HCID 58413201, compound

Participants

Reaction Steps

Trifluoroacetic acid (1 ml) was added to a solution of 4-[2-((3S,5S)-1-tert-butoxycarbonyl-5-hydroxymethyl-pyrrolidin-3-yloxy)-4-fluoro-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid amide (754 mg) in dichloromethane (10 ml). The reaction mixture was stirred for 4 h and a further aliqout of trifluoroacetic acid was added. The reaction mixture was stirred for 1 h again. The solvent was removed in vacuo. The mixture was diluted with dichloromethane and washed with 10% aq. K2CO3. The organic layer was concentrated and the residue was purified by flash column chromatography (silica gel, solvent: 100% dichloromethane→20:1:0,1 dichloromethane: MeOH: NH4OH)

Provenance & Evidence