HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Methylthio)benzyl bromide → {(S)-6-[(R)-5-cyano-4-(4-methylsulfanyl-benzyl)-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Methylthio)benzyl bromide | HCID 11367930 | — |
| Reactant | {(S)-6-[(R)-4-bromo-5-cyano-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester | HCID 86700771 | — |
| Product | {(S)-6-[(R)-5-cyano-4-(4-methylsulfanyl-benzyl)-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester | HCID 86700781 | — |
Reaction Steps
The title compound is prepared from {(S)-6-[(R)-4-bromo-5-cyano-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester and 4-methylsulfanyl-benzyl bromide following a procedure analogous to that described for Intermediate 7. LC (method 4): tR=1.12 min; Mass spectrum (ESI+): m/z=508 [M+Na]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08809376B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-612b7b736afe4770861a073f4497accb |
| Source note | uspto-grants-2014_08 |