HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 240652Generated: October 25, 2026
Hydrochloric Acid → 4-[4-Fluoro-2-(tetrahydro-pyran-4-yloxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methylester
https://huagongshe.com/reaction/240652
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Methyl 4-chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate | HCID 2759834 | — |
| Reactant | 4-Fluoro-2-(oxan-4-yloxy)aniline | HCID 58413079 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-[4-Fluoro-2-(tetrahydro-pyran-4-yloxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methylester | HCID 46182044 | — |
Reaction Steps
To a mixture of 4-chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester (8.5 g) and 4-fluoro-2-(tetrahydro-2H-pyran-4-yloxy)aniline (7.4 g) (intermediate XX) in dioxane (100 ml) was added HCl in dioxan (4M; 0.9 ml). The reaction was stirred at 100° C. overnight. The reaction mixture was allowed to warm to room temperature and water (50 ml) was added. The precipitate was isolated by filtration
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08648068B2 |
|---|
| Source dataset | uspto-grants-2014_02 |
|---|
| ORD ID | ord-f5a5064ede1149bb8dfea67882202a36 |
|---|
| Source note | uspto-grants-2014_02 |
|---|
