反应详情

温度

60 °C

The title compound is prepared from {(S)-6-[(R)-4-bromo-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester (84 mg), 3-methoxy-benzylzinc chloride (0.5 mol/L in tetrahydrofuran, 1.2 mL) and tetrakis(triphenylphosphine)-palladium (23 mg). Degassed tetrahydrofuran (1 mL) is added under Ar atmosphere, and the mixture is heated to 60° C. and shaken at this temperature overnight. The mixture is acidified with 4 N aqueous hydrochloric acid (1 mL) and then neutralized with saturated aqueous ammonia solution. The organic phase is separated, diluted with N,N-dimethylformamide (1 mL), and purified by HPLC on reversed phase (MeCN/water) to give the title compound. LC (method 6): tR=1.17 min.

1. customThe organic phase is separated
2. additiondiluted with N,N-dimethylformamide (1 mL)
3. custompurified by HPLC on reversed phase (MeCN/water)