Hydrochloric Acid → 4-(4-Fluoro-2-(tetrahydro-2H-pyran-4-yloxy)phenylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acid

Participants

Reaction Steps

4-[4-Fluoro-2-(tetrahydro-pyran-4-yloxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methylester (13.45 g) was dissolved in THF (100 ml) and lithium hydroxide (1M; 80.5 ml) was added. The reaction mixture was stirred at room temperature for 5 h. The mixture was acidified with HCl (1M) to pH 2, the resultant precipitate was filtered and washed with water.

Provenance & Evidence