4-Fluorobenzyl bromide → HCID 86700795, compound

HRID 2406530Notes

Reaction equation

HRID 2406530 reaction equation
[CH3:1][O:2][C:3](=[O:27])[CH2:4][C@H:5]1[C:9]2[CH:10]=[CH:11][C:12]([O:14][C@H:15]3[C:23]4[C:18](=[C:19](Br)[C:20]([C:24]#[N:25])=[CH:21][CH:22]=4)[CH2:17][CH2:16]3)=[CH:13][C:8]=2[O:7][CH2:6]1.[F:28][C:29]1[CH:36]=[CH:35][C:32]([CH2:33]Br)=[CH:31][CH:30]=1>>[CH3:1][O:2][C:3](=[O:27])[CH2:4][C@H:5]1[C:9]2[CH:10]=[CH:11][C:12]([O:14][C@H:15]3[C:23]4[C:18](=[C:19]([CH2:33][C:32]5[CH:35]=[CH:36][C:29]([F:28])=[CH:30][CH:31]=5)[C:20]([C:24]#[N:25])=[CH:21][CH:22]=4)[CH2:17][CH2:16]3)=[CH:13][C:8]=2[O:7][CH2:6]1

Participants

3

Reactant 2

HCID 680214-Fluorobenzyl bromideHCID 86700771{(S)-6-[(R)-4-bromo-5-cyano-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester

Product 1

HCID 86700795HCID 86700795, compound

Procedure

The title compound is prepared from {(S)-6-[(R)-4-bromo-5-cyano-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester and 4-fluoro-benzyl bromide following a procedure analogous to that described for Intermediate 7. LC (method 6): tR=1.18 min; Mass spectrum (ESI+): m/z=458 [M+H]+.

Sources & evidence

ORD record
ord-4bfb2562fcfb4a6d81cb86ce1d901664
Source dataset
uspto-grants-2014_08
Patent number
US08809376B2

Reaction notes

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