Hydrochloric Acid → HCID 86700798, compound

Participants

Reaction Steps

A mixture of {(S)-6-[(R)-4-(4-acetoxy-benzyl)-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester (0.19 g), K2CO3 (0.08 g), and methanol (5 ml) is stirred at room temperature for 2 h. The solution is neutralized with 1 N aqueous HCl solution and concentrated. Water is added to the residue, and the resulting mixture is extracted with ethyl acetate. The combined extract is dried (MgSO4) and concentrated. The residue is chromatographed on silica gel (cyclohexane/ethyl acetate) to give the title compound. LC (method 8): tR=1.22 min; Mass spectrum (ESI+): m/z=521 [M+Na]+.

Provenance & Evidence