HuagongsheHuagongshe Chemistry Print Report · For research reference only
{(S)-6-[(R)-4-bromo-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester → HCID 72203366, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | {(S)-6-[(R)-4-bromo-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester | HCID 86700774 | — |
| Reactant | HCID 178478120 | HCID 178478120 | — |
| Catalyst | HCID 178439029 | HCID 178439029 | — |
| Product | HCID 72203366 | HCID 72203366 | — |
Reaction Steps
The title compound is prepared from {(S)-6-[(R)-4-bromo-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester and 4-chloro-benzylzinc chloride following a procedure analogous to that described in Step 6 of Intermediate 1; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene]-(3-chloropyridyl)-palladium(II) dichloride (Pd-PEPPSI-IPr) is used as catalyst. LC (method 3): tR=1.01 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08809376B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-5bbc57ad402e4f448896685b0c0b9624 |
| Source note | uspto-grants-2014_08 |