4-Amino-1-methylpiperidine → HCID 58413210, compound

HRID 240655Notes

Reaction equation

HRID 240655 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:10]3[C:17]([CH3:18])=[C:16]([C:19](O)=[O:20])[S:15][C:11]=3[N:12]=[CH:13][N:14]=2)=[C:4]([O:22][C@@H:23]2[CH2:28][CH2:27][CH2:26][O:25][CH2:24]2)[CH:3]=1.[CH3:29][N:30]1[CH2:35][CH2:34][CH:33]([NH2:36])[CH2:32][CH2:31]1>>[CH3:29][N:30]1[CH2:35][CH2:34][CH:33]([NH:36][C:19]([C:16]2[S:15][C:11]3[N:12]=[CH:13][N:14]=[C:9]([NH:8][C:5]4[CH:6]=[CH:7][C:2]([F:1])=[CH:3][C:4]=4[O:22][C@@H:23]4[CH2:28][CH2:27][CH2:26][O:25][CH2:24]4)[C:10]=3[C:17]=2[CH3:18])=[O:20])[CH2:32][CH2:31]1

Participants

3

Reactant 2

HCID 27375314-Amino-1-methylpiperidineHCID 58413227HCID 58413227, compound

Product 1

HCID 58413210HCID 58413210, compound

Procedure

Prepared analogously to example 10.4 from 4-{4-fluoro-2-[(R)-(tetrahydro-pyran-3-yl)oxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid and 1-methyl-piperidin-4-ylamine.

Sources & evidence

ORD record
ord-86d2c1c2a43e4fb5ab3f1851d850e7af
Source dataset
uspto-grants-2014_02
Patent number
US08648068B2

Reaction notes

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