Methyl 4-chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate → HCID 58413036, compound

HRID 240656Notes

Reaction equation

HRID 240656 reaction equation
[CH3:1][O:2][C:3]([C:5]1[S:14][C:8]2[N:9]=[CH:10][N:11]=[C:12](Cl)[C:7]=2[C:6]=1[CH3:15])=[O:4].[O:16]1[CH2:21][CH2:20][CH2:19][C@@H:18]([O:22][C:23]2[C:28]([NH2:29])=[CH:27][CH:26]=[CH:25][N:24]=2)[CH2:17]1>>[CH3:1][O:2][C:3]([C:5]1[S:14][C:8]2[N:9]=[CH:10][N:11]=[C:12]([NH:29][C:28]3[C:23]([O:22][C@@H:18]4[CH2:19][CH2:20][CH2:21][O:16][CH2:17]4)=[N:24][CH:25]=[CH:26][CH:27]=3)[C:7]=2[C:6]=1[CH3:15])=[O:4]

Participants

3

Reactant 2

HCID 2759834Methyl 4-chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylateHCID 58413066HCID 58413066, compound

Product 1

HCID 58413036HCID 58413036, compound

Procedure

Prepared analogously to example 1.1 from 4-Chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester and 2-[(R)-(Tetrahydro-pyran-3-yl)oxy]-pyridin-3-ylamine

Sources & evidence

ORD record
ord-355ee64c41a54fb5bc982963ea5b541c
Source dataset
uspto-grants-2014_02
Patent number
US08648068B2

Reaction notes

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