Water → HCID 87170972, compound

Participants

Reaction Steps

Thioglycerol (42 μL, 0.5 mmol) was added to a stirred solution of WP1130 (19 mg, 0.05 mmol) in acetonitrile (0.5 mL). The resulting mixture was stirred at room temperature for 17 hours. The mixture was distributed between water and dichloromethane. The separated organic layer was washed with sat. brine, dried over sodium sulfate, and concentrated to an oil. Purification by preparative TLC eluting with hexanes/ethyl acetate (6:4) afforded 20 (20 mg, 82%) as a clear oil: MS (ES+) m/z 492.0 (M+H)+.

Provenance & Evidence