6-Fluoropyridine-2-carboxaldehyde → (E)-2-Cyano-N-(1-(4-(2-(diethylamino)ethoxy)phenyl)butyl)-3-(6-fluoropyridin-2-yl)acrylamide

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Reaction Steps

The title compound was prepared by using a similar procedure as described for the preparation of 33 except that 6-fluoropicolinaldehyde was used instead of 6-bromopicolinaldehyde. This produced crude product which was purified by flash silica gel column chromatography, eluting with 4:96 methanol/dichloromethane, to give 34 (105 mg, 61%) as a yellow oil: MS (ES+) m/z 439.2 (M+H)+.

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