N,N-Dimethyl-1,3-propanediamine → HCID 67396564, compound

HRID 240662Notes

Reaction equation

HRID 240662 reaction equation
[CH3:1][C:2]1[C:10]2[C:9]([NH:11][C:12]3[C:13]([O:18][C@H:19]4[CH2:23][CH2:22][O:21][CH2:20]4)=[N:14][CH:15]=[CH:16][CH:17]=3)=[N:8][CH:7]=[N:6][C:5]=2[S:4][C:3]=1[C:24]([OH:26])=O.[CH3:27][N:28]([CH3:33])[CH2:29][CH2:30][CH2:31][NH2:32]>>[CH3:27][N:28]([CH3:33])[CH2:29][CH2:30][CH2:31][NH:32][C:24]([C:3]1[S:4][C:5]2[N:6]=[CH:7][N:8]=[C:9]([NH:11][C:12]3[C:13]([O:18][C@H:19]4[CH2:23][CH2:22][O:21][CH2:20]4)=[N:14][CH:15]=[CH:16][CH:17]=3)[C:10]=2[C:2]=1[CH3:1])=[O:26]

Participants

3

Reactant 2

HCID 7993N,N-Dimethyl-1,3-propanediamineHCID 67395860HCID 67395860, compound

Product 1

HCID 67396564HCID 67396564, compound

Procedure

Prepared analogously to example 10.4 from 5-methyl-4-{2-[(S)-(tetrahydro-furan-3-yl)oxy]-pyridin-3-ylamino}-thieno[2,3-d]pyrimidine-6-carboxylic acid and N1,N1-dimethyl-propane-1,3-diamine.

Sources & evidence

ORD record
ord-e11c6f3afce44485b4e9b184c40ae32d
Source dataset
uspto-grants-2014_02
Patent number
US08648068B2

Reaction notes

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