HuagongsheHuagongshe Chemistry Print Report · For research reference only
Glutaric anhydride → 5-(2-Hex-1-enyl-indol-1-yl)-5-oxo-pentanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Glutaric anhydride | HCID 7940 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 2-Hex-1-enyl-1H-indole | HCID 66644149 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 5-(2-Hex-1-enyl-indol-1-yl)-5-oxo-pentanoic acid | HCID 66644267 | — |
Reaction Steps
To a solution of 2-hex-1-enyl-1H-indole in DMSO was added KOH at RT and this was stirred for 30 minutes. Dihydro-pyran-2,6-dione was added to the reaction mixture and stirred for 3 hours. The reaction was treated with saturated ammonium chloride and ethyl acetate. The product was purified by column chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08809382B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-7b00a14085534980960298f724de382a |
| Source note | uspto-grants-2014_08 |