HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic anhydride → HCID 66643978, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic anhydride | HCID 9845 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | (R)-1-Methyl hydrogen 3-methylglutarate | HCID 6999733 | — |
| Reactant | HCID 14299246 | HCID 14299246 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 66643978 | HCID 66643978 | — |
Reaction Steps
In flask A postassium-tert-butoxide solution in THF was added to a solution of 2-hexyl-1H-indole and stirred for 30 minutes. In another flask B trifluoro acetic anhydride was added to a solution of 3(R)-methyl-pentanedioic acid monomethyl ester in methylene chloride and stirred for 20 minutes. The solution in flask A was transferred to solution in flask B and the reaction mixture was stirred for 3 hours. The reaction was treated with saturated ammonium chloride and ethyl acetate. The product was purified by column chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08809382B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-03c3c5151ca24f3385c57d5e4f360594 |
| Source note | uspto-grants-2014_08 |