HRID240664

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID18946151

tert-Butyl 4-aminoazepane-1-carboxylate

C11H22N2O2

结构：Cc1c(C(=O)O)sc2ncnc(Nc3ccc(F)cc3O[C@H]3CCOC3)c12

HCID58413126

未命名化合物

PRODUCTS

生成物

结构：Cc1c(C(=O)NC2CCCN(C(=O)OC(C)(C)C)CC2)sc2ncnc(Nc3ccc(F)cc3O[C@H]3CCOC3)c12

HCID67397042

未命名化合物

PROCEDURE

实验过程

Prepared analogously to example 1.4 from 4-{4-fluoro-2-[(S)-(tetrahydro-furan-3-yl)oxy]-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid and 4-amino-azepane-1-carboxylic acid tert-butyl ester.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c6e4274ba2394ff89b884410571fe392
来源数据集: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08648068B2
来源说明: uspto-grants-2014_02

反应 SMILES

[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:10]3[C:17]([CH3:18])=[C:16]([C:19](O)=[O:20])[S:15][C:11]=3[N:12]=[CH:13][N:14]=2)=[C:4]([O:22][C@H:23]2[CH2:27][CH2:26][O:25][CH2:24]2)[CH:3]=1.[C:28]([O:32][C:33]([N:35]1[CH2:41][CH2:40][CH2:39][CH:38]([NH2:42])[CH2:37][CH2:36]1)=[O:34])([CH3:31])([CH3:30])[CH3:29]>>[C:28]([O:32][C:33]([N:35]1[CH2:41][CH2:40][CH2:39][CH:38]([NH:42][C:19]([C:16]2[S:15][C:11]3[N:12]=[CH:13][N:14]=[C:9]([NH:8][C:5]4[CH:6]=[CH:7][C:2]([F:1])=[CH:3][C:4]=4[O:22][C@H:23]4[CH2:27][CH2:26][O:25][CH2:24]4)[C:10]=3[C:17]=2[CH3:18])=[O:20])[CH2:37][CH2:36]1)=[O:34])([CH3:31])([CH3:29])[CH3:30]