HuagongsheHuagongshe Chemistry Print Report · For research reference only
Glutaric anhydride → 5-(2-Hexyl-1-methyl-1H-indol-3-yl)-5-oxo-pentanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Glutaric anhydride | HCID 7940 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 2-Hexyl-1-methyl-1H-indole | HCID 15213961 | — |
| Reactant | Dimethylalumanylium chloride | HCID 16686359 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Hexane | HCID 8058 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 5-(2-Hexyl-1-methyl-1H-indol-3-yl)-5-oxo-pentanoic acid | HCID 49804580 | — |
Reaction Steps
To a solution of 2-hexyl-1-methyl-1H-indole in methylene chloride at 0° C. was added dimethyl aluminum chloride solution in hexane. The reaction mixture was stirred for 30 minutes. To this solution dihydro-pyran-2,6-dione was added at 0° C. and the reaction mixture was stirred for 3 hours. The reaction was treated with saturated ammonium chloride and ethyl acetate. The product was purified by column chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08809382B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-89cce1339ac74a27bf3c1f8266cd0ad0 |
| Source note | uspto-grants-2014_08 |