Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 240666Generated: October 25, 2026

Methyl 4-chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate → 5-Methyl-4-[2-(tetrahydro-pyran-4-yloxy)-pyridin-3-ylamino]-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester

https://huagongshe.com/reaction/240666

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 4-chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylateHCID 2759834—
Reactant2-(tetrahydro-2H-pyran-4-yloxy)pyridin-3-amineHCID 53256608—
Product5-Methyl-4-[2-(tetrahydro-pyran-4-yloxy)-pyridin-3-ylamino]-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl esterHCID 46182086—

Reaction Steps

Prepared analogously to 1.1 from 4-chloro-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester and 2-(tetrahydro-pyran-4-yloxy)-pyridin-3-ylamine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08648068B2
Source datasetuspto-grants-2014_02
ORD IDord-7df5321078834fe8b80c24a4db1c086c
Source noteuspto-grants-2014_02