HRID2406665

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID16686359

未命名化合物

HCID66644172

未命名化合物

结构：C[C@@H](CC(=O)Cl)CC(=O)OC[Si](c1ccccc1)(c1ccccc1)C(C)(C)C

HCID86665260

未命名化合物

PRODUCTS

生成物

结构：CCCCCCc1cc2ccc(Cl)cc2n1C(=O)C[C@H](C)CC(=O)OC[Si](c1ccccc1)(c1ccccc1)C(C)(C)C

HCID66644137

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

To the solution of 5-chloro-2-hexyl-1-methyl-1H-indole in methylene chloride was added dimethyl aluminum chloride at 0 0 C and was stirred for 60 minutes. Then to this mixture, 4-chlorocarbonyl-3-(R)-methyl-butyric acid (tert-butyl-diphenyl-silanyl)-methyl ester was added and stirred for 3 hours. The reaction was quenched with saturated ammonium chloride solution and extracted with ethyl acetate. The product was purified by column chromatography.

WORKUP

后处理

stirringstirred for 3 hours
customThe reaction was quenched with saturated ammonium chloride solution
extractionextracted with ethyl acetate
customThe product was purified by column chromatography

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b1c0abd4039f4229a8120d64977fc0a5
来源数据集: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08809382B2
来源说明: uspto-grants-2014_08

反应 SMILES

Cl[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7](C)[C:6]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])=[CH:5]2.[Cl-:18].C[Al+]C.[C:22]([Si:26]([CH2:39][O:40][C:41](=[O:49])[CH2:42][C@@H:43]([CH3:48])[CH2:44][C:45](Cl)=[O:46])([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)([CH3:25])([CH3:24])[CH3:23]>C(Cl)Cl>[C:22]([Si:26]([CH2:39][O:40][C:41](=[O:49])[CH2:42][C@@H:43]([CH3:48])[CH2:44][C:45]([N:7]1[C:8]2[C:4](=[CH:3][CH:2]=[C:10]([Cl:18])[CH:9]=2)[CH:5]=[C:6]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])=[O:46])([C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1)[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)([CH3:24])([CH3:25])[CH3:23]