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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 240667Generated: October 25, 2026

Lithium Hydroxide → 5-methyl-4-(2-(tetrahydro-2H-pyran-4-yloxy)pyridin-3-ylamino)thieno[2,3-d]pyrimidine-6-carboxylic acid

https://huagongshe.com/reaction/240667

Reaction equation

Participants

RoleNameHCIDCharge
ReactantLithium HydroxideHCID 3939—
ReactantSodium HydroxideHCID 14798—
Reactant5-Methyl-4-[2-(tetrahydro-pyran-4-yloxy)-pyridin-3-ylamino]-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl esterHCID 46182086—
Product5-methyl-4-(2-(tetrahydro-2H-pyran-4-yloxy)pyridin-3-ylamino)thieno[2,3-d]pyrimidine-6-carboxylic acidHCID 58413102—

Reaction Steps

Prepared analogously to 1.2. from 5-methyl-4-[2-(tetrahydro-pyran-4-yloxy)-pyridin-3-ylamino]-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester. Lithium hydroxide was replaced by sodium hydroxide (2M).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08648068B2
Source datasetuspto-grants-2014_02
ORD IDord-39c3d6b714c0492ebe6c2d239bce70bd
Source noteuspto-grants-2014_02