HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → 5-[5-Chloro-2-(5-methyl-hexyl)-indol-1-yl]-3-methyl-5-oxo-pentanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 3-Methylglutaric anhydride | HCID 77828 | — |
| Reactant | 5-chloro-2-(5-methyl-hexyl)-1H-indole | HCID 68746927 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 5-[5-Chloro-2-(5-methyl-hexyl)-indol-1-yl]-3-methyl-5-oxo-pentanoic acid | HCID 66646961 | — |
Reaction Steps
To the solution of 5-chloro-2-(5-methyl-hexyl)-1H-indole in DMSO was added KOH at RT and was stirred for 30 minutes. Then to this mixture, 4-methyl-dihydro-pyran-2,6-dione was added and stirred for 3 hours. The reaction was quenched with saturated ammonium chloride solution and extracted with ethyl acetate. The product was purified by column chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08809382B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-47ae22176cfd49e08dbcbaa8486fadb8 |
| Source note | uspto-grants-2014_08 |