HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2406728Generated: October 30, 2026
Pyrazole → 7-nitro-3-(1H-pyrazol-1-yl)quinoline
https://huagongshe.com/reaction/2406728
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyrazole | HCID 1048 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | trans-N,N'-dimethyl-1,2-cyclohexanediamine | HCID 2733821 | — |
| Reactant | N,N,2-trimethylaziridine-1-carboxamide | HCID 11007919 | — |
| Reactant | 3-Iodo-7-nitroquinoline | HCID 68618821 | — |
| Catalyst | Copper iodide | HCID 83717 | — |
| Solvent | Water | HCID 962 | — |
| Product | 7-nitro-3-(1H-pyrazol-1-yl)quinoline | HCID 68618824 | 99.9% |
Reaction Steps
Pyrazole (20 mg), trans-N,N′-dimethylcyclohexane-1,2-diamine (24 μl), copper iodide (14 mg), and cesium carbonate (73 mg) were added to an N,N-dimethylpropyleneurea (2 ml) solution containing 3-iodo-7-nitroquinoline (45 mg), followed by stirring at 70° C. for 2.5 hours in a nitrogen atmosphere. Water was added to the reaction solution, an insoluble precipitate was purified by silica gel chromatography (n-hexane:ethyl acetate=1:0 to 0:1), and a light yellow solid of 7-nitro-3-(1H-pyrazol-1-yl)quinoline (36 mg) was thus obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08809371B2 |
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| Source dataset | uspto-grants-2014_08 |
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| ORD ID | ord-44c1f2a78d6b49e2b45dd94c6c7d20a0 |
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| Source note | uspto-grants-2014_08 |
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