HCID 68028001, compound → 1354223-61-2

HRID 2406731Notes

Reaction equation

HRID 2406731 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH2:14][CH2:13][CH2:12][C:11]2=[O:15])=[N:8][CH:9]=1)([O-])=O>[Pd].CO>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH2:14][CH2:13][CH2:12][C:11]2=[O:15])=[N:8][CH:9]=1

Participants

4

Reactant 1

HCID 68028001HCID 68028001, compound

Product 1

HCID 840621391354223-61-2Yield 109.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A methanol (20 ml) solution containing 1-(5-nitropyridin-2-yl)pyrrolidin-2-one (31 mg) was prepared and subjected to a hydrogenation reaction (30° C.; 1 bar; flow rate: 1 ml/min; 10% Pd/C) using H-cube™. Then, the solvent was distilled away under reduced pressure, and a purple solid of 1-(5-aminopyridin-2-yl)pyrrolidin-2-one (29 mg) was thus obtained.

Workup

  1. customwas prepared
  2. distillationThen, the solvent was distilled away under reduced pressure

Sources & evidence

ORD record
ord-acff3cf40f424417821120f95d1498f4
Source dataset
uspto-grants-2014_08
Patent number
US08809371B2

Reaction notes

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