HCID 86683865, compound → HCID 55291136, compound

HRID 2406737Notes

Reaction equation

HRID 2406737 reaction equation
[CH:1]1([N:4]2[C:8]([N+:9]([O-])=O)=[CH:7][N:6]=[CH:5]2)[CH2:3][CH2:2]1>[Pd].CO>[CH:1]1([N:4]2[C:8]([NH2:9])=[CH:7][N:6]=[CH:5]2)[CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 86683865HCID 86683865, compound

Product 1

HCID 55291136HCID 55291136, compoundYield 41.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A methanol (15 ml) solution containing 1-cyclopropyl-5-nitro-1H-imidazole (60 mg) was prepared and subjected to hydrogenation reaction (80° C.; 50 bar; flow rate: 2 ml/min; 10% Pd/C) using H-cube™. Thereafter, the solvent was distilled away under reduced pressure, and a purple solid of 1-cyclopropyl-1H-imidazol-5-amine (20 mg) was thus obtained.

Workup

  1. customwas prepared
  2. distillationThereafter, the solvent was distilled away under reduced pressure

Sources & evidence

ORD record
ord-6837a86e7da242dea7488e2c3b14440b
Source dataset
uspto-grants-2014_08
Patent number
US08809371B2

Reaction notes

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