HCID 86683874, compound → HCID 68624056, compound

HRID 2406747Notes

Reaction equation

HRID 2406747 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[C:12]([N:13]3[CH:17]=[CH:16][CH:15]=[N:14]3)=[CH:11][C:10]([N+:18]([O-])=O)=[CH:9][N:8]=2)[CH2:3][CH2:2]1>[Pd].CO>[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[N:8]=[CH:9][C:10]([NH2:18])=[CH:11][C:12]=2[N:13]2[CH:17]=[CH:16][CH:15]=[N:14]2)[CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 86683874HCID 86683874, compound

Product 1

HCID 68624056HCID 68624056, compoundYield 94%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A methanol (5 ml) solution containing 2-morpholino-5-nitro-3-(1H-pyrazol-1-yl)pyridine (37 mg) was prepared and was subjected to a hydrogenation reaction (room temperature; 1 bar; flow rate: 1 ml/min; 10% Pd/C) using H-cube™. Then, the solvent was distilled away under reduced pressure, and a white solid of 6-morpholino-5-(1H-pyrazol-1-yl)pyridin-3-amine (31 mg) was thus obtained.

Workup

  1. customwas prepared
  2. distillationThen, the solvent was distilled away under reduced pressure

Sources & evidence

ORD record
ord-e7f6e0a71cd1414eae003db35a46e427
Source dataset
uspto-grants-2014_08
Patent number
US08809371B2

Reaction notes

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