Hydrochloric Acid → (R)-3-(pyrrolidin-2-ylmethoxy)picolinamide dihydrochloride

Participants

Reaction Steps

A solution of (R)-tert-butyl 2-((2-carbamoylpyridin-3-yloxy)methyl)pyrrolidine-1-carboxylate (3.43 g, 10.7 mmol, EXAMPLE 1 Step 2) in 4.0 M hydrogen chloride in ethyl acetate (100 mL) was stirred at room temperature for 5 h. Diisopropyl ether (150 mL) was added to the mixture, and the formed white precipitate was collected by filtration. The precipitate was dried under reduced pressure to give 2.89 g (92%) of the title compound as a white solid.

Provenance & Evidence