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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2406784Generated: October 31, 2026

Indole-2-carboxylic acid → HCID 178513800, compound

https://huagongshe.com/reaction/2406784

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIndole-2-carboxylic acidHCID 72899—
Reactant(R)-5-chloro-3-(pyrrolidin-2-ylmethoxy)picolinamide dihydrochlorideHCID 66962076—
ReactantHCID 178525710HCID 178525710—
ProductHCID 178513800HCID 178513800—

Reaction Steps

The title compound was prepared according to the procedure described in Step 1 of EXAMPLE 3 using (R)-5-chloro-3-(pyrrolidin-2-ylmethoxy)picolinamide dihydrochloride (EXAMPLE 29 Step 5) and trans-4-(trifluoromethyl)cyclohexanecarboxylic acid instead of (R)-3-(pyrrolidin-2-ylmethoxy)picolinamide dihydrochloride and indole-2-carboxylic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08809380B2
Source datasetuspto-grants-2014_08
ORD IDord-12d6c2ebcaac4bc4b8ea5e6ec8f992d5
Source noteuspto-grants-2014_08