Ethanolamine → (R)-tert-butyl 2-((2-(2-hydroxyethylcarbamoyl)pyridin-3-yloxy)methyl)pyrrolidine-1-carboxylate
Reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][C@@H:9]1[CH2:13][O:14][C:15]1[C:16]([C:21]([OH:23])=O)=[N:17][CH:18]=[CH:19][CH:20]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:24]([CH2:26][NH2:27])[OH:25]>>[OH:25][CH2:24][CH2:26][NH:27][C:21]([C:16]1[C:15]([O:14][CH2:13][C@H:9]2[CH2:10][CH2:11][CH2:12][N:8]2[C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7])=[CH:20][CH:19]=[CH:18][N:17]=1)=[O:23]Participants
3
Procedure
The title compound was prepared according to the procedure described in Step 5 of EXAMPLE 31 from (R)-3-((1-(tert-butoxycarbonyl)pyrrolidin-2-yl)methoxy)picolinic acid (EXAMPLE 33 Step 2) using ethanolamine instead of ammonium chloride.
Sources & evidence
- ORD record
- ord-1d5972c6e9914776a9e2c810a6cc916f
- Source dataset
- uspto-grants-2014_08
- Patent number
- US08809380B2
Reaction notes
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