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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2406794Generated: October 31, 2026

(R)-N-(2-hydroxyethyl)-3-(pyrrolidin-2-ylmethoxy)picolinamide dihydrochloride → HCID 178523455, compound

https://huagongshe.com/reaction/2406794

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(R)-N-(2-hydroxyethyl)-3-(pyrrolidin-2-ylmethoxy)picolinamide dihydrochlorideHCID 66962029—
ReactantHCID 178493765HCID 178493765—
ReactantHCID 178525710HCID 178525710—
ProductHCID 178523455HCID 178523455—

Reaction Steps

The title compound was prepared according to the procedure described in Step 5 of EXAMPLE 31 using (R)—N-(2-hydroxyethyl)-3-(pyrrolidin-2-ylmethoxy)picolinamide dihydrochloride (EXAMPLE 33 Step 4) and trans-4-(trifluoromethyl)cyclohexanecarboxylic acid instead of ammonium chloride and 5-methoxy-3-(((R)-1-(trans-4-(trifluoromethyl)cyclohexanecarbonyl)pyrrolidin-2-yl)m ethoxy)picolinic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08809380B2
Source datasetuspto-grants-2014_08
ORD IDord-f51204bb72ba4d29b0c1eb4146c0b892
Source noteuspto-grants-2014_08