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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2406798Generated: October 27, 2026

3-Hydroxy-5-chloropyridine → HCID 178470239, compound

https://huagongshe.com/reaction/2406798

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Hydroxy-5-chloropyridineHCID 582305—
ReactantEthyl 3-hydroxypicolinateHCID 15080989—
ReactantHCID 178520947HCID 178520947—
ProductHCID 178470239HCID 178470239—

Reaction Steps

The title compound was prepared according to the procedure described in Step 1 of EXAMPLE 29 using [(2S)-1-{[trans-4-(trifluoromethyl)cyclohexyl]carbonyl}pyrrolidin-2-yl]methanol (EXAMPLE 60 Step 1) and ethyl 3-hydroxypicolinate instead of (R)-tert-butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate and 5-chloropyridin-3-ol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08809380B2
Source datasetuspto-grants-2014_08
ORD IDord-edfb3ed8566e484aa73977a6a81b0a9e
Source noteuspto-grants-2014_08