HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(4,4-Difluorocyclohexyl)acetic acid → (R)-ethyl 3-((1-(2-(4,4-difluorocyclohexyl)acetyl)pyrrolidin-2-yl)methoxy)picolinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(4,4-Difluorocyclohexyl)acetic acid | HCID 53420743 | — |
| Reactant | (R)-ethyl 3-(pyrrolidin-2-ylmethoxy)picolinate bis(trifluoroacetic acid) salt | HCID 86762606 | — |
| Reactant | HCID 178493765 | HCID 178493765 | — |
| Product | (R)-ethyl 3-((1-(2-(4,4-difluorocyclohexyl)acetyl)pyrrolidin-2-yl)methoxy)picolinate | HCID 86666100 | — |
Reaction Steps
The title compound was prepared according to the procedure described in Step 5 of EXAMPLE 31 using (R)-ethyl 3-(pyrrolidin-2-ylmethoxy)picolinate bis(trifluoroacetic acid) salt (EXAMPLE 34 Step 1) and 2-(4,4-difluorocyclohexyl)acetic acid instead of ammonium chloride and 5-methoxy-3-(((R)-1-(trans-4-(trifluoromethyl)cyclohexanecarbonyl)pyrrolidin-2-yl)methoxy)picolinic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08809380B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-6c35e3c7e0dd42ae93850f78a9fa7974 |
| Source note | uspto-grants-2014_08 |