HRID2406812

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID72899

Indole-2-carboxylic acid

C9H7NO2

结构：CCOC(=O)c1ncccc1OC[C@H]1C[C@@H](OCOCc2ccccc2)CN1

HCID66962098

未命名化合物

HCID178525710

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)c1ncccc1OC[C@H]1C[C@@H](OCOCc2ccccc2)CN1C(=O)[C@H]1CC[C@H](C(F)(F)F)CC1

HCID178470241

未命名化合物

PROCEDURE

实验过程

The title compound was prepared according to the procedure described in Step 1 of EXAMPLE 3 using ethyl 3-(((2R,4R)-4-(benzyloxymethoxy)pyrrolidin-2-yl)methoxy)picolinate (EXAMPLE 79 Step 4) and trans-4-(trifluoromethyl)cyclohexanecarboxylic acid instead of (R)-3-(pyrrolidin-2-ylmethoxy)picolinamide dihydrochloride and indole-2-carboxylic acid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2914371d9c3e4c0e873608bcf7030e59
来源数据集: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08809380B2
来源说明: uspto-grants-2014_08

反应 SMILES

[CH2:1]([O:8][CH2:9][O:10][C@H:11]1[CH2:15][NH:14][C@@H:13]([CH2:16][O:17][C:18]2[C:19]([C:24]([O:26][CH2:27][CH3:28])=[O:25])=[N:20][CH:21]=[CH:22][CH:23]=2)[CH2:12]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:29][C:30]([F:41])([F:40])[C@H:31]1[CH2:36][CH2:35][C@H:34]([C:37](O)=[O:38])[CH2:33][CH2:32]1.N1C2C(=CC=CC=2)C=C1C(O)=O>>[CH2:1]([O:8][CH2:9][O:10][C@H:11]1[CH2:15][N:14]([C:37]([C@H:34]2[CH2:33][CH2:32][C@H:31]([C:30]([F:29])([F:40])[F:41])[CH2:36][CH2:35]2)=[O:38])[C@@H:13]([CH2:16][O:17][C:18]2[C:19]([C:24]([O:26][CH2:27][CH3:28])=[O:25])=[N:20][CH:21]=[CH:22][CH:23]=2)[CH2:12]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1