Indole-2-carboxylic acid → HCID 178431203, compound

HRID 2406817Notes

Reaction equation

HRID 2406817 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([O:11][CH2:12][C:13]2([CH3:30])[CH2:17][CH2:16][N:15]([C:18]([C@H:20]3[CH2:25][CH2:24][C@H:23]([C:26]([F:29])([F:28])[F:27])[CH2:22][CH2:21]3)=[O:19])[CH2:14]2)[C:5]([C:8]([NH2:10])=O)=[N:6][CH:7]=1.FC(F)(F)[C@H]1CC[C@H](C(O)=O)CC1.N1C2C(=CC=CC=2)C=C1C(O)=O>>[Cl:1][C:2]1[CH:3]=[C:4]([O:11][CH2:12][C:13]2([CH3:30])[CH2:17][CH2:16][N:15]([C:18]([C@H:20]3[CH2:25][CH2:24][C@H:23]([C:26]([F:27])([F:28])[F:29])[CH2:22][CH2:21]3)=[O:19])[CH2:14]2)[C:5]([C:8]#[N:10])=[N:6][CH:7]=1

Participants

4

Reactant 3

HCID 72899Indole-2-carboxylic acidHCID 178431204HCID 178431204, compoundHCID 178525710HCID 178525710, compound

Product 1

HCID 178431203HCID 178431203, compound

Procedure

The title compound was prepared according to the procedure described in Step 3 of EXAMPLE 1 using 5-chloro-3-((3-methylpyrrolidin-3-yl)methoxy)picolinonitrile dihydrochloride (EXAMPLE 84, Step 4) and trans-4-(trifluoromethyl)cyclohexanecarboxylic acid instead of (R)-3-(pyrrolidin-2-ylmethoxy)picolinamide dihydrochloride and indole-2-carboxylic acid.

Sources & evidence

ORD record
ord-a9897c85747147e993c0ef3bb4b56173
Source dataset
uspto-grants-2014_08
Patent number
US08809380B2

Reaction notes

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