Indole-2-carboxylic acid → HCID 178470235, compound

HRID 2406821Notes

Reaction equation

HRID 2406821 reaction equation
C(N[C:9](=[O:36])[C:10]1[C:15]([O:16][CH2:17][C:18]23[CH2:23][CH:22]2[CH2:21][N:20]([C:24]([C@H:26]2[CH2:31][CH2:30][C@H:29]([C:32]([F:35])([F:34])[F:33])[CH2:28][CH2:27]2)=[O:25])[CH2:19]3)=[CH:14][CH:13]=[CH:12][N:11]=1)C1C=CC=CC=1.F[C:38](F)(F)[C@H:39]1CC[C@H](C(O)=O)CC1.N1C2C(=CC=CC=2)C=C1C(O)=[O:60]>>[F:34][C:32]([F:35])([F:33])[C@H:29]1[CH2:28][CH2:27][C@H:26]([C:24]([N:20]2[CH2:21][CH:22]3[C:18]([CH2:17][O:16][C:15]4[C:10]([C:9]([O:36][CH2:38][CH3:39])=[O:60])=[N:11][CH:12]=[CH:13][CH:14]=4)([CH2:23]3)[CH2:19]2)=[O:25])[CH2:31][CH2:30]1

Participants

4

Reactant 3

HCID 72899Indole-2-carboxylic acidHCID 178522819HCID 178522819, compoundHCID 178525710HCID 178525710, compound

Product 1

HCID 178470235HCID 178470235, compound

Procedure

The title compound was prepared according to the procedure described in Step 3 of EXAMPLE 1 using ethyl 3-((3-azabicyclo[3.1.0]hexan-1-ylmethoxy)picolinate dihydrochloride (EXAMPLE 88, Step 2) and trans-4-(trifluoromethyl)cyclohexanecarboxylic acid instead of (R)-3-(pyrrolidin-2-ylmethoxy)picolinamide dihydrochloride and indole-2-carboxylic acid.

Sources & evidence

ORD record
ord-6d567ae4166b4c04b921c740e04a8d04
Source dataset
uspto-grants-2014_08
Patent number
US08809380B2

Reaction notes

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