3-Hydroxy-5-chloropyridine → HCID 66961874, compound

HRID 2406823Notes

Reaction equation

HRID 2406823 reaction equation
[OH:1][CH2:2][CH:3]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4]1.O[C:16]1[C:17]([C:22]([O:24][CH2:25][CH3:26])=[O:23])=[N:18][CH:19]=[CH:20][CH:21]=1.ClC1C=C(O)C=NC=1>>[C:11]([O:10][C:8]([N:5]1[CH2:6][CH2:7][CH:3]([CH2:2][O:1][C:16]2[C:17]([C:22]([O:24][CH2:25][CH3:26])=[O:23])=[N:18][CH:19]=[CH:20][CH:21]=2)[CH2:4]1)=[O:9])([CH3:14])([CH3:13])[CH3:12]

Participants

4

Reactant 3

HCID 5823053-Hydroxy-5-chloropyridineHCID 5237175tert-Butyl 3-(hydroxymethyl)pyrrolidine-1-carboxylateHCID 15080989Ethyl 3-hydroxypicolinate

Product 1

HCID 66961874HCID 66961874, compound

Procedure

The title compound was prepared according to the procedure described in Step 1 of EXAMPLE 29 using tert-butyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate and ethyl 3-hydroxypicolinate instead of (R)-tert-butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate and 5-chloropyridin-3-ol.

Sources & evidence

ORD record
ord-bb487066400e4323a9938f60a977e8b6
Source dataset
uspto-grants-2014_08
Patent number
US08809380B2

Reaction notes

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