HCID 178470238, compound → HCID 178524884, compound

HRID 2406825Notes

Reaction equation

HRID 2406825 reaction equation
[F:1][C:2]([F:30])([F:29])[C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9]([N:11]2[CH2:15][CH2:14][CH:13]([CH2:16][O:17][C:18]3[C:19]([C:24]([O:26]CC)=[O:25])=[N:20][CH:21]=[CH:22][CH:23]=3)[CH2:12]2)=[O:10])[CH2:5][CH2:4]1.COC1C=C(OC[C@H]2CCCN2C([C@H]2CC[C@H](C(F)(F)F)CC2)=O)C(C(OCC)=O)=NC=1>>[F:30][C:2]([F:1])([F:29])[C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9]([N:11]2[CH2:15][CH2:14][CH:13]([CH2:16][O:17][C:18]3[C:19]([C:24]([OH:26])=[O:25])=[N:20][CH:21]=[CH:22][CH:23]=3)[CH2:12]2)=[O:10])[CH2:5][CH2:4]1

Participants

3

Reactant 2

HCID 178470238HCID 178470238, compoundHCID 178470258HCID 178470258, compound

Product 1

HCID 178524884HCID 178524884, compound

Procedure

The title compound was prepared according to the procedure described in Step 4 of EXAMPLE 31 using ethyl 3-((1-(trans-4-(trifluoromethyl)cyclohexanecarbonyl)pyrrolidin-3-yl)methoxy)picolinate (EXAMPLE 92 Step 3) in stead of ethyl 5-methoxy-3-(((R)-1-(trans-4-(trifluoromethyl)cyclohexanecarbonyl)pyrrolidin-2-yl)methoxy)picolinate.

Sources & evidence

ORD record
ord-d1fd10525cfc49f890f1f04d3504a748
Source dataset
uspto-grants-2014_08
Patent number
US08809380B2

Reaction notes

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