Acetic Anhydride → HCID 66974003, compound

HRID 2406837Notes

Reaction equation

HRID 2406837 reaction equation
[CH2:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[C:6]([O:12][CH3:13])[CH:5]=1)[CH2:2][CH3:3].[C:14](OC(=O)C)(=[O:16])[CH3:15]>[Cl-].[Zn+2].[Cl-]>[C:14]([C:9]1[C:4]([CH2:1][CH2:2][CH3:3])=[CH:5][C:6]([O:12][CH3:13])=[C:7]([O:10][CH3:11])[CH:8]=1)(=[O:16])[CH3:15]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 1232331,2-Dimethoxy-4-propylbenzene

Product 1

HCID 66974003HCID 66974003, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 3007855ZincchlorideCatalyst

Procedure

Following the same procedure as in Example 3 a), a mixture of 18.02 g (0.1 mole) of 4-propyl-1.2-dimethoxybenzene, 5.13 g (0.05 moles) of acetic anhydride and 0.7 g (5 mmoles) of anhydrous zinc chloride was reacted at 80-90° C. for 6 hrs. After washing, separation of the organic phase and evaporation u.v (20° C./21 mbar) a residue was obtained that after purification on silica gel column (eluant n-hexane: ethyl acetate 90/10 v/v) gives 8.0 g (0.037 moles) of 1-acetyl-6-propyl-3,4-dimethoxybenzene.

Workup

  1. customwas reacted at 80-90° C. for 6 hrs
  2. washAfter washing
  3. customseparation of the organic phase and evaporation u.v (20° C./21 mbar) a residue
  4. customwas obtained that
  5. customafter purification on silica gel column (eluant n-hexane: ethyl acetate 90/10 v/v)

Sources & evidence

ORD record
ord-31c8c590936c49e4bd191ccb8b6764c8
Source dataset
uspto-grants-2014_08
Patent number
US08809389B2

Reaction notes

Loading…