Acetic Anhydride → HCID 66973888, compound

HRID 2406844Notes

Reaction equation

HRID 2406844 reaction equation
[CH2:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:11][CH2:10][CH2:9][C:8]=2[CH:12]=1)[CH2:2][CH3:3].[C:13](OC(=O)C)(=[O:15])[CH3:14]>[Cl-].[Zn+2].[Cl-]>[CH2:1]([C:4]1[C:5]([C:13](=[O:15])[CH3:14])=[CH:6][C:7]2[O:11][CH2:10][CH2:9][C:8]=2[CH:12]=1)[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 20791366HCID 20791366, compound

Product 1

HCID 66973888HCID 66973888, compoundYield 31.2%

Reagents, catalysts & solvents 1

HCID 3007855ZincchlorideCatalyst

Procedure

Following the same procedure as in Example 3a), 46.3 g (0.286 moles) of 5-propyl-2,3-dihydrobenzofuran were reacted with 29.2 g (0.286 moles) of acetic anhydride and 3.9 g (0.029 moles) of anhydrous zinc chloride. After washing and work up, 18.2 g of 5-propyl-6-acetyl-2,3-dihydrobenzofuran was obtained as an oil (129-131° C./0.5 mbar) (title 93%).

Workup

  1. washAfter washing

Sources & evidence

ORD record
ord-d77ad4ee8f9e48398519482a5e2c5ff2
Source dataset
uspto-grants-2014_08
Patent number
US08809389B2

Reaction notes

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