Potassium Carbonate → HCID 66974008, compound

Participants

Reaction Steps

Following the same procedure as in Example 3 c), a mixture of 5.0 g (0.026 moles) of 5-propyl-6-hydroxy-2,3-dihydrobenzofuran (title 93.5%), 3.9 g (0.028 moles) of anhydrous potassium carbonate in ml 30 of acetone was added with 3.7 g (0.028 moles) of 1-bromo-2-butyne: the mixture was heated to reflux for 6 hrs. After cooling to room temperature, the mixture was filtered and the filtrate evaporated u.v (20° C./21 mbar). The residue so obtained was purified by chromatography on silica column (eluant n-hexane/ethyl acetate 3/1 (v/v)). A liquid product (3.8 g, purity 96%) was obtained, whose NMR and MS analyses corresponded to those of the aforementioned compound.

Provenance & Evidence