Stannous Chloride → Methyl 5-amino-4'-methylbiphenyl-3-carboxylate

HRID 2406884Notes

Reaction equation

HRID 2406884 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([C:14]2[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=2)[CH:8]=[C:9]([N+:11]([O-])=O)[CH:10]=1)=[O:4].Cl[Sn]Cl>>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([C:14]2[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=2)[CH:8]=[C:9]([NH2:11])[CH:10]=1)=[O:4]

Participants

3

Reactant 2

HCID 24479Stannous ChlorideHCID 57851213Methyl 3-(4-methylphenyl)-5-nitrobenzoate

Product 1

HCID 57850917Methyl 5-amino-4'-methylbiphenyl-3-carboxylate

Procedure

4′-Methyl-5-nitro-biphenyl-3-carboxylic acid methyl ester was reduced using SnCl2 using the procedure of step 4 of preparation 6 to afford 5-Amino-4′-methyl-biphenyl-3-carboxylic acid methyl ester, MS (M+H)=242.

Workup

  1. customthe procedure of step 4 of preparation 6

Sources & evidence

ORD record
ord-4ff2f75defc346758b3bc20c148f37d9
Source dataset
uspto-grants-2014_08
Patent number
US08809402B2

Reaction notes

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