Sodium Carbonate → HCID 71294337, compound

Participants

Reaction Conditions

Reaction Steps

5-(4-Chloro-3-fluoro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-3-pyridinecarboxylic acid methyl ester (97 mg, 267 μmol) was dissolved in ethanol (2 mL) to give a light yellow solution. Hydrazine monohydrate (134 mg, 130 μl, 2.67 mmol) was added under argon. The reaction mixture was stirred under argon at reflux temperature (85° C.) for 5 h. Subsequently the reaction mixture was poured into 10 mL saturated aqueous Na2CO3 solution and extracted with isopropyl acetate (2×20 mL). The organic layers were combined, dried with Na2SO4 and concentrated in vacuo to give the title compound (63 mg, 65%) as off-white solid; MS (ESI) 361.8 (M−H)−.

Provenance & Evidence