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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 240692Generated: October 25, 2026

1-Aminopiperidin-4-OL → 5-(4-chlorophenyl)-6-(cyclopropylmethoxy)-N-(4-hydroxypiperidin-1-yl)-3-pyridinecarboxamide

https://huagongshe.com/reaction/240692

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Aminopiperidin-4-OLHCID 12125645—
Reactant5-(4-Chlorophenyl)-6-(cyclopropylmethoxy)nicotinic acidHCID 66687482—
Product5-(4-chlorophenyl)-6-(cyclopropylmethoxy)-N-(4-hydroxypiperidin-1-yl)-3-pyridinecarboxamideHCID 71294371—

Reaction Steps

The title compound was synthesized in analogy to Example 1 using 5-(4-chlorophenyl)-6-(cyclopropylmethoxy)-3-pyridinecarboxylic acid (CAN 1018782-76-7) and 1-amino-4-piperidinol (CAN 79414-82-7) as starting materials; MS (EI) 402.4 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08648099B2
Source datasetuspto-grants-2014_02
ORD IDord-9e176afc87b34658aa32e50b739fc6ef
Source noteuspto-grants-2014_02