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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 240699Generated: October 25, 2026

1-Aminopiperidin-4-OL → 5-Cyclohexyl-N-(4-hydroxypiperidin-1-yl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxamide

https://huagongshe.com/reaction/240699

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Aminopiperidin-4-OLHCID 12125645—
Reactant5-Cyclohexyl-6-(2,2,2-trifluoroethoxy)nicotinic acidHCID 71293952—
Product5-Cyclohexyl-N-(4-hydroxypiperidin-1-yl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxamideHCID 71294089—

Reaction Steps

The title compound was synthesized in analogy to Example 1 using 5-cyclohexyl-6-(2,2,2-trifluoro-ethoxy)-3-pyridinecarboxylic acid and 1-amino-4-piperidinol (CAN 79414-82-7) as starting materials; LC-MS (UV peak area/ESI) 96.4%, 402.1991 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08648099B2
Source datasetuspto-grants-2014_02
ORD IDord-2eeb7b93cccc47458664bd6c7721f77c
Source noteuspto-grants-2014_02