tert-Butyl 4-aminopiperazine-1-carboxylate → HCID 71294282, compound

HRID 240700Notes

Reaction equation

HRID 240700 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:20](O)=[O:21])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:4][CH:3]=1.[CH3:23][C:24]([O:27][C:28]([N:30]1[CH2:35][CH2:34][N:33]([NH2:36])[CH2:32][CH2:31]1)=[O:29])([CH3:26])[CH3:25]>>[C:24]([O:27][C:28]([N:30]1[CH2:31][CH2:32][N:33]([NH:36][C:20]([C:10]2[CH:11]=[N:12][C:13]([O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[C:8]([C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)[CH:9]=2)=[O:21])[CH2:34][CH2:35]1)=[O:29])([CH3:23])([CH3:25])[CH3:26]

Participants

3

Reactant 2

HCID 22029174tert-Butyl 4-aminopiperazine-1-carboxylateHCID 666869715-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid

Product 1

HCID 71294282HCID 71294282, compound

Procedure

The title compound was synthesized in analogy to Example 1 using 5-(4-chlorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid (CAN 1018782-82-5) and 4-amino-1-piperazinecarboxylic acid 1,1-dimethylethyl ester (CAN 118753-66-5) as starting materials; MS (EI) 515.2 (M+H)+.

Sources & evidence

ORD record
ord-448437067c854d1b87078951bf3f6839
Source dataset
uspto-grants-2014_02
Patent number
US08648099B2

Reaction notes

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